2017 Fiscal Year Final Research Report
Quantitative analyses of total neuron numbers at three different neuronal levels in relation to olfactory function
| Project/Area Number |
15K06737
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
福島 菜奈恵 信州大学, 学術研究院医学系, 准教授 (90334888)
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| Research Collaborator |
YOKOUCHI Kumiko
KUROIWA Masafumi
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 嗅上皮 / 嗅球 / 外側嗅索 / 嗅皮質 / 嗅覚 |
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| Outline of Final Research Achievements |
Cerebral cortical ablations in neonatal rats revealed that the anterior olfactory nucleus was not related to the olfactory discriminative ability and that the size of the remaining cortical regions of the piriform cortex and olfactory tubercle was important for the ability. Combined lesions of sectioning of the lateral olfactory tract and injections of a neurotoxin in adult rats showed similar results to the experiments in neonates and further uncovered that the minimal cortical size for the olfactory discriminative ability was approximately 20% of the normal cortical size. Transection of the lateral olfactory tract in neonatal rats revealed that functional revovery occurred as early as 10 days after tract transection and that areas and densities of regenerated nerve components essential for functional recovery were approximately 40% and 60% of the normal values in the olfactory cortices at the level of the olfactory tubercle.
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| Free Research Field |
神経科学 神経解剖学 嗅覚
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