Control of tangential cell migration in layer formation of the developing optic tectum

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06740
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Fukushima Medical University
• Principal Investigator: WATANABE YUJI 福島県立医科大学, 医学部, 講師 (80301042)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 発生 / 神経 / 視蓋 / 層形成 / 細胞移動

Outline of Final Research Achievements

During embryonic brain development, groups of particular neuronal cells migrate tangentially to participate in
the formation of a laminated structure. We report the dynamics of tangential cell movement in superficial layers of developing chick optic tectum. Confocal time-lapse microscopy revealed that vigorous cell migration continued during 1 week, where horizontally elongated superficial cells spread out tangentially. Motile cells exhibited exploratory behavior in reforming the branched leading processes to determine their pathway, and intersected with each other for dispersion. The tangentially migrating cells were eventually distributed in the outer stratum griseum et fibrosum superficiale and differentiated into neurons of various morphologies. These results revealed the cellular dynamics for widespread neuronal distribution in the superficial layers of the developing optic tectum,

Free Research Field

神経発生学