2017 Fiscal Year Final Research Report
Molecular mechanism of Reelin-induced neuronal aggregation in the developing mouse cereberal cortex
| Project/Area Number |
15K06745
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Keio University |
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Principal Investigator |
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| Research Collaborator |
Inoue Seika
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 発生 / 大脳新皮質 / 層構造 / 細胞凝集 / 細胞接着 / Reelin / N-cadherin |
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| Outline of Final Research Achievements |
The mammalian neocortex has the six layered structure organized by excitatory neurons, which enables higher brain functions. A secretary molecule ‘Reelin’ is essential for the layer formation, but the molecular mechanism based on Reelin for the layer formation remains to be elucidated. The purpose of the current project is to clarify cellular and molecular mechanisms to form the layered structure based on Reelin during cortical development.
In this study, we found that Reelin-inducible neuronal aggregate was mediated by N-cadherin-based cellular adhesion and that this promotion of cellular adhesion by Reelin was in a transient manner. Moreover, we revealed p120 catenin and Nck were involved in this N-cadherin-based cellular adhesion. These results were presented in several scientific meetings and published in an international journal.
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| Free Research Field |
神経発生
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