Structural basis for centrifugal regulation of synaptic circuit in the olfactory bulb

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06748
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Nerve anatomy/Neuropathology
• Research Institution: Kawasaki Medical School
• Principal Investigator: Toida Kazunori 川崎医科大学, 医学部, 教授 (40253405)
• Research Collaborator: 清蔭 恵美 川崎医療福祉大学, 教授 ; 堀江 沙和 川崎医科大学, 助教 ; 松野 岳志 川崎医科大学, 大学院生 ; 濱本 真一 川崎医科大学, 大学院生
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 神経回路 / 嗅球 / シナプス結合 / 遠心性調節 / セロトニン / アセチルコリン / ノルアドレナリン

Outline of Final Research Achievements

This research aims to establish structural basis for centrifugal regulation of synaptic circuit in the olfactory bulb, from our previously consistent studies with correlated laser and electron microscopy. We have paid special attention to serotonergic, cholinergic and noradrenergic neurons projecting to the olfactory bulb. These neurons have been examined by single-neuronal labeling as well as wide-filed laser/electron microscopic analyses, correlated laser and volume EM study. Results indicated interesting findings exhibiting layer-specific distribution by three kinds of centrifugal projections to the olfactory bulb. These findings have suggested more elaborate features of regulation of the synaptic circuit in the olfactory bulb than previously considered.

Free Research Field

神経解剖学