A study on neuroprotection by glia-derived lipoproteins against nerve injury

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06781
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Tokyo University of Pharmacy and Life Science
• Principal Investigator: Hayashi Hideki 東京薬科大学, 薬学部, 講師 (90508657)
• Research Collaborator: Vance Jean E. アルバータ大学, 医学部, 教授
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 緑内障 / リポタンパク質 / グルタミン酸

Outline of Final Research Achievements

Glaucoma is one of the neurodegenerative disorders and the leading cause of blindness in Japan. In our previous study, apolipoprotein E-containing lipoproteins strongly protect primary cultured retinal ganglion cells from glutamate-induced neurodegeneration. Here, we determined a novel neuroprotective mechanism of apolipoprotein E-containing lipoproteins and defined roles of an inhibitory factor against the protective effect of apolipoprotein E-containing lipoproteins.

Free Research Field

神経科学