Manipulation of the activity of parvalbumin-expressing interneurons against post-traumatic stress disorder

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06784
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Hoshi University
• Principal Investigator: Tamura Hideki 星薬科大学, 先端生命科学研究所, 特任准教授 (80437516)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ペリニューロナルネット / パルブアルブミン / 扁桃体 / cFos / 恐怖条件づけ / 記憶痕跡

Outline of Final Research Achievements

Perineuronal nets (PNNs), proteoglycan-rich extracellular matrix structures, are thought to be expressed around inhibitory neurons and contribute to critical periods of brain function and synaptic plasticity. However, in some specific brain regions such as the amygdala, PNNs were predominantly expressed around excitatory neurons. These neurons were recruited during auditory fear conditioning and memory retrieval. Indeed, the activation of PNN-expressing excitatory neurons predicted cognitive performance.

Free Research Field

神経科学