Molecular mechanisms of the DISC1 functions in astrocyte-a study that is focused on the relationship with schizophrenia-

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06790
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Neurochemistry/Neuropharmacology
• Research Institution: Kindai University
• Principal Investigator: TOHYAMA Masaya 近畿大学, 東洋医学研究所, 教授 (40028593)
• Co-Investigator(Kenkyū-buntansha): 田中 貴士 近畿大学, 付置研究所, 助教 (30734694) ; 清水 尚子 近畿大学, 東洋医学研究所, 助教 (50572731) ; 宮田 信吾 近畿大学, 東洋医学研究所, 教授 (70403194)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: DISC1 / アストロサイト / 統合失調症

Outline of Final Research Achievements

The major psychiatric disorders such as schizophrenia are thought to be multifactorial diseases related to both genetic and environmental factors. However, the genes responsible and the molecular mechanisms underlying the pathogenesis of schizophrenia remain unclear. We previously reported that abnormalities of disrupted-in-Schizophrenia-1 (DISC1) might cause major psychiatric disorders such as schizophrenia. In our previous study, we observed that DISC1 expression detected in primary astrocytes cultures.
In this study, we further identified that DISC1 expressions were observed in both fibrillary astrocyte and radial astrocyte in the mice brain. Our data suggest that DISC1 in astrocyte might be possibly related to schizophrenia.

Free Research Field

神経化学