2017 Fiscal Year Final Research Report
Development of mouse models of osteoarthritis targeting the Gfd5 gene
| Project/Area Number |
15K06797
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Iwate University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 変形性関節症 / モデル動物 / GDF5 / コンジェニックマウス |
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| Outline of Final Research Achievements |
The GDF5 gene is reported to be associated with osteoarthritis (OA) in mice and humans. M451 mouse strain, which possesses the missense mutation (W408R) in Gdf5, develops an early-onset osteoarthritis (OA) of the elbow joint. However, detailed evaluation of M451 strain as OA model animals has not been carried out. We generated congenic mouse strains in which W408R mutation was introduced into the genetic background C57BL/6 or STR/ort. We confirmed the duplicability of an early-onset OA in the C57BL/6 congenic strain. Articular cartilage lesion in the STR/ort congenic strain seemed more severe than that that in STR/ort. These two congenic strains are useful to develop novel OA model animals.
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| Free Research Field |
実験動物学
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