Development of an inhalation anesthesia method that takes practical and animal protection into consideration for mice and rats

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06813
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: Kyoto University
• Principal Investigator: KONNO Kenjiro 京都大学, iPS細胞研究所, 准教授 (30323348)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: マウス / ラット / 吸入麻酔 / 気管挿管 / 動物愛護 / マスク麻酔 / 外科処置 / 疾患モデル

Outline of Final Research Achievements

Informations on both vital signs and various parameters concerning respiration during anesthesia using SomnoSuite; Low-Flow Anesthesia System (MAS) purchased at this grant to the tracheal-intubated mice and rats were recorded and analyzed. As a result, it was suggested that in inhalation anesthesia using MAS for about 1 hour, relatively safe anesthesia can be applied to the rats as well as humans. On the other hand, in the case of the mice, it seemed that more detailed examination was necessary. Furthermore, both the mice and rats showed that it takes time to recover their weight after the inhalation anesthesia, suggesting not only intraoperative management but also perioperative management is important.

Free Research Field

実験動物医学を専門とする獣医師