2017 Fiscal Year Final Research Report
Mechanisms of induction of cancer stem cells in the bone microenvironment ; involvement of drug resistance for bone metastasis
| Project/Area Number |
15K06837
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Nagasaki University (2017)
Nagoya City University (2015-2016) |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | Bone microenvironment / TGF-beta / Cancer stem cell |
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| Outline of Final Research Achievements |
In the present study, anti bone metastasis agents which have different targets, was examined to identify the mechanisms for the induction of CSCs in the bone MI. Treatment of bone modifying agents, targeting osteoclasts, did not change the ratio of CSCs in the bone ME as well as subQ ME and treatment of TGFβ signaling inhibitor, significantly reduced that of CSC in the bone ME. Interestingly, inappropriate treatments of anti cancer agent or androgen, targeting prostate cancer cells, significantly increased the ratio of CSCs in the bone ME in our model using androgen independent or dependent prostate cancer cells. Our results indicated that bone MI would be good niche for CSCs, and TGFβ would be involved in the induction of CSCs, and anti-cancer agents combined with those targeting CSC may plays a key role to eliminate the drug resistant bone metastasis of prostate or breast cancer.
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| Free Research Field |
Pathology, 病理学
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