2017 Fiscal Year Final Research Report
Premetastatic niche enhances liver metastasis
| Project/Area Number |
15K06842
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor biology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
DEGUCHI ATSUKO 東京女子医科大学, 医学部, 助教 (10422932)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 肝転移 / 微小環境 / 大腸がん / S100A8 |
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| Outline of Final Research Achievements |
During tumor progression, inflammatory signaling develops tumor microenvironment. Similarly, metastatic tumors can prepare a premetastatic niche at their favorable organs. To establish novel therapeutic strategy against liver metastasis, we investigated the mechanism(s) by which hepatic premetastatic niche factor enhance cancer metastasis. We also examined the effect of S100A8 on liver metastasis in mouse models, and found that S100A8 played a role in liver metastasis.
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| Free Research Field |
腫瘍生物学
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