2017 Fiscal Year Final Research Report
Development of TP53 signature in vitro diagnostics (IVD)
| Project/Area Number |
15K06851
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Tumor diagnostics
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | バイオマーカー / 遺伝子発現プロファイル / TP53 / 予後予測 / 治療効果予測 |
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| Outline of Final Research Achievements |
The purpose of this study is to develop a simple in vitro diagnostic kit aiming at clinical application of TP53 signature.
Probe set of TP53 signature for nCounter was created. TP53 signature data was obtained from the early stage breast cancer cohort (n = 174). Univariate and multivariate analysis results revealed that TP53 signature is the most relevant factor to RFS. In addition, comprehensive gene expression analysis was performed, and the prognostic potential of TP53 signature was compared with Mammaprint, Oncotype DX, and PAM 50. It was shown that TP53 signature had the highest prognostic predictability.
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| Free Research Field |
臨床腫瘍学
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