Search of the responsible gene mutations associated with familial hereditary lung cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06856
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor diagnostics
• Research Institution: Nagasaki University
• Principal Investigator: FUKUSHIMA Kiyoyasu 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (00746620)
• Co-Investigator(Kenkyū-buntansha): 久保 亨 長崎大学, 熱帯医学研究所, 客員研究員 (50444873) ; 永安 武 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80284686) ; 松本 桂太郎 長崎大学, 医歯薬学総合研究科(医学系), 講師 (80404268)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 肺腺癌 / がん遺伝子 / 遺伝子変異

Outline of Final Research Achievements

We identified a family lineage of possible autosomal dominant familial lung cancer, which has 24 lung cancer pants within three generations.
In order to detect responsible cancer genes, we performed genome-wide analysis for three lung cancer patients and six cancer-free individuals within the family. Initially we selected 17 gene mutations by linkage-exome approach. And then by mutation-function analysis, five candidate gene mutations were identified.Now we are verifying mutations in those five genes are responsible for this familial hereditary lung cancer.

Free Research Field

呼吸器内科学