Molecular analysis of malignant ascites formation by single-cell RNA-sequencing

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06861
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor diagnostics
• Research Institution: Japanese Foundation for Cancer Research
• Principal Investigator: Mori Seiichi 公益財団法人がん研究会, がんプレシジョン医療研究センター 次世代がん研究シーズ育成プロジェクト, プロジェクトリーダー (10334814)
• Co-Investigator(Kenkyū-buntansha): 加藤 一喜 公益財団法人がん研究会, 有明病院 婦人科, 医長 (80399451) ; 杉山 裕子 公益財団法人がん研究会, 有明病院 細胞診断部, 部長 (80322634)
• Research Collaborator: Rika Nishiko 公益財団法人がん研究会, がんプレシジョン医療研究センター 次世代がん研究シーズ育成プロジェクト, 特任研究助手
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: １細胞解析 / 漿液性卵巣がん / 悪性腹水 / がん細胞 / 炎症細胞 / 中皮細胞

Outline of Final Research Achievements

Although patients with serous ovarian cancer very often accumulate malignant ascites, the molecular mechanism has not been well elucidated and effective therapeutics against ascites formation has neither been available. In this research, we have been performing basic research to understand the molecular etiology. We have been performing single-cell RNA-seq analyses of ascites constituent cells, such as cancer cells, inflammatory cells, mesothelial cells, for comprehensively understanding the intercellular interaction and intracellular pathway abnormality.

Free Research Field

がんゲノム学　生物情報科学