Development and mechanism analysis of small molecules affecting tumor-stromal cell interactions

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06888
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Tumor therapeutics
• Research Institution: Microbial Chemistry Research Foundation
• Principal Investigator: KAWADA Manabu 公益財団法人微生物化学研究会, 微生物化学研究所, 部長 (20300808)
• Co-Investigator(Renkei-kenkyūsha): INOUE Hiroyuki 公益財団法人微生物化学研究会, 微生物化学研究所沼津支所, 研究員 (50601548) ; AMEMIYA Masahide 公益財団法人微生物化学研究会, 微生物化学研究所第1生物活性研究部, 研究員 (10232000) ; YOSHIDA Junjiro 公益財団法人微生物化学研究会, 微生物化学研究所第1生物活性研究部, 上級研究員 (20712706)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 抗がん剤 / がん間質 / 天然物

Outline of Final Research Achievements

We have been finding small molecule modulators of tumor-stromal cell interactions among natural compounds using coculture systems of cancer and stromal cells. Here we report the mechanism of action of intervenolin, a novel compound that we found recently, and a new modulator for the lung tumor-stromal cell interactions. We have found that intervenolin stimulates stromal cells to secrete cancer-growth inhibitory factors. Furthermore, we found activity in an actinomycete culture and isolated 8-azaguanine by coculture system of lung cancer and stromal cells. It is suggested that the action of 8-azaguanine needs the direct contact of cells and is independent on nucleotide metabolism.

Free Research Field

がん化学療法