Study for epigenetic abnormality of microRNA in lymphoma biology

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06907
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Medical genome science
• Research Institution: The University of Tokyo
• Principal Investigator: Yamagishi Makoto 東京大学, 大学院新領域創成科学研究科, 特任講師 (90625261)
• Project Period (FY): 2015-10-21 – 2018-03-31
• Keywords: microRNA / エピジェネティクス / 悪性リンパ腫 / HTLV-1 / ATL / 遺伝子翻訳

Outline of Final Research Achievements

Defenseless signaling is the true nature of the cancer cell. By using RISC-capture assay for normal and clinical samples, this study demonstrates that the signaling cascade habitually confronts epigenetic interference composed of miRNA group in human cells. In malignant lymphoma cells, aberrant action of epigenetic factors hierarchically influences the functional miRNA en masse, enhancing target gene translation and coherent active crosstalk involving NF-kB, Ras-Erk, and Akt-mTOR. We illustrate an example of a biological masterplan comprised of signaling networks, miRNAs, translation regulation, and epigenetic mechanisms. Furthermore, we show that appropriate inhibition of the signaling cascades or the epigenetic abnormality appear to be effective for malignant lymphoma.

Free Research Field

分子生物学、ゲノム医科学、分子腫瘍学