Development of methods for making glycan atlas, and data collection for database publishing

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K06991
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Niigata University
• Principal Investigator: Natsuka Shunji 新潟大学, 自然科学系, 教授 (00243163)
• Co-Investigator(Renkei-kenkyūsha): SUZUKI Noriko 新潟大学, 自然科学系, 助教 (50401237)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 糖鎖 / グライコーム / 網羅的解析 / データベース

Outline of Final Research Achievements

A preparing method for glycan atlas, which is a comprehensive database of glycan structure and expression level, was adapted to glycan molecules of various forms. Using this method, we succeeded in comprehensively analyzing the changes in glycan structure during the embryonic development of zebrafish, and some of these results have been published. On the other hand, we also succeeded to accumulate data on structure and expression level by analyzing glycan structure of glycoproteins and animal tissues and published on internet as 2 dimensional glycan maps. This study overcame the technical problems for producing of mice and human glycan atlases.

Free Research Field

機能生物化学