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2019 Fiscal Year Final Research Report

Molecular clutch between ATP and proton motors in ATP synthase

Research Project

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Project/Area Number 15K07013
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Functional biochemistry
Research InstitutionRikkyo University

Principal Investigator

KATO-YAMADA Yasuyuki  立教大学, 理学部, 教授 (80386507)

Project Period (FY) 2015-04-01 – 2020-03-31
Keywords生体エネルギー変換 / 共役 / 活性調節 / 脱共役
Outline of Final Research Achievements

(1)It was shown that inter-subunit interactions within rotor components is altered under uncoupling state. (2)Recovery of the coupling by the inter-subunit cross-linking has not been observed so far. (3)It was shown that one third of the TFoF1 molecules may be incomplete.(4) A mutant epsilon subunit with higher affinity for ATP was obtained. (5) The physiological significance of the regulation of ATP synthase in Bacillus subtilis was clarified.

Free Research Field

機能生物科学

Academic Significance and Societal Importance of the Research Achievements

いまだ不明な点の多い、ATP合成酵素の条件的脱共役状態について、さまざまな知見を得ることができた。更に研究を続け分子機構の解明へとつなげたい。
ATP合成酵素の活性調節機構は原核生物と真核生物では異なるため、抗生物質の作用点として注目されている。条件的脱共役も、εサブユニットが構造変化をするバクテリアATP合成酵素のみが持つ性質であると考えられることから、同様に全く新しい抗生物質の作用点として活用することも期待される。

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Published: 2021-02-19  

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