Structural basis of energy transduction mechanism in the respiratory terminal enzymes.

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07029
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Biophysics
• Research Institution: University of Hyogo
• Principal Investigator: Muramoto Kazumasa 兵庫県立大学, 生命理学研究科, 准教授 (50305679)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 生物物理 / ナノバイオ / 蛋白質 / 酵素 / 呼吸鎖 / 生体エネルギー変換 / X線結晶構造解析 / 酵素反応速度論的解析

Outline of Final Research Achievements

Respiratory chains in mitochondrial and bacterial membrane transfer hydrogen ions (protons) by using energy released from the redox reaction (electron transfer), and efficiently generates energy available for the life. To understand the energy transduction mechanism, I studied molecular structure and function of the respiratory terminal enzymes. The results showed that structural property of the catalytic site and the proton transfer pathway, and functional property of the electron transfer between the enzyme and its electron donor.

Free Research Field

生物物理学