Analysis of the signal transduction network regulating cell motility

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07043
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Cell biology
• Research Institution: Kyoto University
• Principal Investigator: Katoh Hironori 京都大学, 生命科学研究科, 准教授 (50303847)
• Co-Investigator(Renkei-kenkyūsha): NEGISHI Manabu 京都大学, 大学院生命科学研究科, 教授 (60201696)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 細胞 / がん / シグナル伝達

Outline of Final Research Achievements

Cell migration contributes to a variety of diseases including tumor metastasis. It is important to elucidate molecular mechanisms underlying the regulation of cell migration to provide new therapeutic targets. In this study, we focused on the interaction between ligand-independent EphA2 receptor signaling and growth factor signaling, both of which play key roles in regulation of cell migration. We found that 1) hepatocyte growth factor (HGF) induces activation of EphA2 during epithelial-mesenchymal transition in epithelial cells, 2) SGEF activity is regulated by its tyrosine phosphorylation, 3) EphA2 is phosphorylated and activated by RSK in response to epidermal growth factor stimulation in glioblastoma cells.

Free Research Field

細胞生物学