2017 Fiscal Year Final Research Report
Search for YAP/TAZ-regulating factors
| Project/Area Number |
15K07052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | University of Occupational and Environmental Health, Japan (2016-2017)
Kyushu University (2015) |
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Principal Investigator |
HIKASA Hiroki 産業医科大学, 医学部, 講師 (40596839)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | Hippo経路 / YAP/TAZ / 活性制御 |
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| Outline of Final Research Achievements |
In order to elucidate the molecular basis of Hippo pathway that is a tumor-suppressive signal, we performed cell-based high throughput screening and mass spectrometry to search for genes and compounds which control or functionally interact with Hippo pathway. We successfully identified several compounds including ivermectin and its derivative milbemycin D as mediators of Hippo pathway and applied for patents. In addition, we revealed that Hippo pathway drives a tumor- suppressive pathway that is dependent on Lin28B, a microRNA regulator and an oncoprotein.
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| Free Research Field |
細胞生物学、分子生物学
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