Cell chirality induced left-right asymmetric rotation of internal organs

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07077
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Developmental biology
• Research Institution: Osaka University
• Principal Investigator: Inaki Mikiko 大阪大学, 理学研究科, 助教 (10747679)
• Co-Investigator(Renkei-kenkyūsha): MATSUNO Kenji 大阪大学, 大学院理学研究科, 教授 (60318227)
• Research Collaborator: HONDA Hisao 神戸大学, 大学院医学研究科, 客員教授 (10289118)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 器官形成 / 左右非対称性 / 細胞キラリティ / 細胞移動 / ライブイメージング / コンピューターシミュレーション

Outline of Final Research Achievements

The Drosophila hindgut, which is a part of the digestive tract, is firstly formed as a symmetric structure, then rotates 90 degrees around the left screw, resulting in a left-right asymmetric shape. It is known that the hindgut cells are left-right asymmetric inclining to the left before the rotation, and they become symmetric after the rotation, suggesting a relationship with the hindgut rotation. However, it has not been elucidated what kind of cellular movement generates the asymmetric morphology of the hindgut.
In this study, we found that the novel cell behavior named "cell slide" is important for changing internal organs to asymmetrical form by performing live imaging and computer simulation of the Drosophila embryonic hindgut rotation.

Free Research Field

発生生物学