2017 Fiscal Year Final Research Report
An analysis of cerebellar histogenesis generated from human pluripotent stem cells
| Project/Area Number |
15K07089
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Developmental biology
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| Research Institution | Institute of Physical and Chemical Research |
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Principal Investigator |
Muguruma Keiko 国立研究開発法人理化学研究所, 多細胞システム形成研究センター, 専門職研究員 (30209978)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 小脳 / ヒト多能性幹細胞 / プルキンエ細胞 / 神経分化 / 三次元立体培養 / 自己組織化 / 脳オルガノイド |
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| Outline of Final Research Achievements |
The R&D PI was engaged in the pioneering works on the development of the self-organizing culture of pluripotent stem cells (PSCs) for brain tissue formation (brain organoid). Using this technique, she developed efficient methods for differentiation of PSCs into cerebellar neurons and cerebellar tissues. In this R&D project, she succeeded in construction of human disease models for cerebellar ataxia by differentiation of the patient-derived iPSCs.
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| Free Research Field |
神経科学、神経発生学、幹細胞生物学
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