2017 Fiscal Year Final Research Report
Effects of endocrine disruptors on the HPG axis of neonatal mice
Project/Area Number |
15K07132
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Morphology/Structure
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Research Institution | Yokohama City University |
Principal Investigator |
Sato Tomomi 横浜市立大学, 生命ナノシステム科学研究科(八景キャンパス), 教授 (40295506)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | エストロゲン |
Outline of Final Research Achievements |
In the mouse ovary, neonatal exposure to estrogens or endocrine disruptors result in reproductive abnormalities including anovulation, hypertrophy-hyperplasia of the interstitial tissues and induction of polyovular follicles due to the alterations of hypothalamus-pituitary-axis. Our previous reports show that neonatal diethylstilbestrol (DES) exposure causes defeminization in the hypothalamus of female mice, however, the regulation of the pituitary gonadotropins is different from that in male mice. To investigate the effects of neonatal exposure to DES on the hypothalamus, immunohistochemistry of neurokinin B and estrogen receptor α was performed in DES-treated mice. In addition, microarray analysis revealed that neonatal DES treatment induced changes in the gene expression of the hypothalamus.
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Free Research Field |
生殖生物学
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