2017 Fiscal Year Final Research Report
Analysis of the regulation for oxidative stress in cysteine metabolism related to Coenzyme Q
| Project/Area Number |
15K07360
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Shimane University |
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Principal Investigator |
Kaino Tomohiro 島根大学, 生物資源科学部, 准教授 (90541706)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | Coenzyme Q / ubiquinone / cysteine |
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| Outline of Final Research Achievements |
The growth of fission yeast (S. pombe) CoQ deficient mutants required the addition of cysteine (Cys) or glutathione for antioxidant to the medium, but the affect for gene expression in CoQ deficient mutants have not been elucidated. When the gene expression of the CoQ deficient mutant was analyzed by microarray, the genes of transporter for ion or sulfur compounds were upregulated. The mutant of cysteine synthase gene show the sensitive for hydrogen peroxide and paraquat and the level of reactive oxygen species (ROS) were induced.
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| Free Research Field |
遺伝子工学
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