2017 Fiscal Year Final Research Report
Reanalysis of the metabolome data by considering the mitochondrial status
| Project/Area Number |
15K07363
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied microbiology
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | メタボローム / 発酵 / 酵母 / ミトコンドリア |
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| Outline of Final Research Achievements |
Fermentation microbes such as yeast are exposed to extreme anaerobiosis during fermentation. Since mitochondria shrink in such environments, the role of mitochondria in the metabolism of yeast has not been studied in detail. However, this notion has hampered biosynthesis of complex substances that are related to mitochondrial metabolism.
In this study, we prepared respirative, fermentative and middle status yeasts, and studied their metabolome. From the metabolome data, we could construct a PLS regression equation to exactly predict the status of yeasts with high statistical significance. This knowledge will enable prediction of the respirative status of yeasts whose metabolomes were analyzed.
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| Free Research Field |
応用微生物学
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