2017 Fiscal Year Final Research Report
Research for new anti-melanoma agents targeting dermcidin
| Project/Area Number |
15K07417
|
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
|
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| Research Institution | Kindai University (2017)
Kitasato University (2015-2016) |
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Principal Investigator |
|
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 抗がん / 海洋微生物 / メラノーマ |
|---|
| Outline of Final Research Achievements |
Melanoma cells are thought the worst cancer cells. We researched for finding the melanoma selective anti-cancer agents from the culture broth of marine-derived microorganisms. We screened more than 10,000 culture broths. As a result, we found three new anti-cancer agents. Isomethoxyneihumicin was isolated from the culture broth of marine actinomycete Nocardiopsis alba KM6-1 which had been collected at Chichizima. Chlokamycin was isolated from marine Streptomyces sp. MA2-12. Additionally, one new compound showing strong activity against some melanoma cells was isolated from marine-derived fungus collected at Okinawa.
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| Free Research Field |
海洋天然物
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