2017 Fiscal Year Final Research Report
Synthetic studies and chemical biology of biologicaly active natural tetramic acids
| Project/Area Number |
15K07418
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Bioorganic chemistry
|
|---|
| Research Institution | Tokyo University of Agriculture |
|---|
Principal Investigator |
Yajima Arata 東京農業大学, 生命科学部, 准教授 (30328546)
|
|---|
| Research Collaborator |
Ohki Chiaki
|
|---|
| Project Period (FY) |
2015-04-01 – 2018-03-31
|
| Keywords | 天然物化学 / 有機合成化学 |
|---|
| Outline of Final Research Achievements |
Synthesis of Signermycin B with histidine kinase WalK inhibitory activity was investigated. We could design the substrate for intramolecular Diels-Alder reaction and investigate the construction of the decaline ring system.
Next, we synthesized ancolinoside A aglycone having type 1 Mattrix proteinase inhibitory activity. On the basis of the comparison of synthetic products and natural products, we were able to determine the absolute configuration of natural products.
Regarding the synthesis of ilicicolins, ring formation by oxidative reaction conditions was examined for the pyridone ring-forming reaction.
|
| Free Research Field |
農芸化学
|
