2017 Fiscal Year Final Research Report
A study on the food development for the prevention of the angiogenesis
| Project/Area Number |
15K07422
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Food science
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 血管新生 / リノレン酸 / エレオステアリン酸 / 共役リノレン酸 / 共役リノール酸 / キリ / ニガウリ |
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| Outline of Final Research Achievements |
In the current study, the antiangiogenic effects of ESA were investigated in
vitro. ESA also inhibited the formation of capillary-like networks by human umbilical vein endothelial cells (HUVEC) and moderately inhibited HUVEC proliferation and migration in a dose-dependent manner. The mechanism by which ESA inhibited angiogenesis was through activation of peroxisome proliferator-activated receptor (PPAR) γ and induction of apoptosis in HUVEC. We thus demonstrated that, like troglitazone, ESA is a PPARγ ligand, and that it activates PPARγ induces apoptosis in HUVEC, and inhibits angiogenesis.
Our findings suggest that ESA has potential use as a therapeutic dietary supplement and medicine for minimizing tumor angiogenesis.
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| Free Research Field |
食品機能学
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