2017 Fiscal Year Annual Research Report
Mechanisms and functions of neuropeptides and amino acids to adapt heat-stress
| Project/Area Number |
15K07694
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| Research Institution | Kyushu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
豊後 貴嗣 広島大学, 生物圏科学研究科, 教授 (40325361)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | Heat-stress / Chicks (layer) / Chicks (broiler) / Thermotolerance / NPY / GnIH / L-Leucine / L-Citrulline |
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| Outline of Annual Research Achievements |
In this project, I had two broader aspects as follows: 1) neuropeptides and 2) amino acids to examine their roles under heat stress. As for neuropeptides, the anti-stress functions of neuropeptide Y (NPY) and its receptor Y5-mediated hypothermic action have been revealed and reported (Eltahan et al., 2017. Physiological Reports, 5: e13511). NPY central injection increased plasma taurine (Eltahan et al., 2017. Physiological Reports, 5: e13511). We have found a novel amino acid, taurine can reduce body temperature. Now, the taurine findings under preparation of a manuscript. A differential expression pattern of gonadotropin-inhibitory hormone (GnIH) has been found under feeding and fasting conditions in heat-exposed chicks (MS under submission). On the other hand, L-leucine has been found to afford heat stress tolerance in male, but not female chicks (Han et al., 2018 Journal of Thermal Biology, 71:74-82). The changes of amino acids and heat-shock proteins in heat-exposed chicks by in ovo L-leucine have been submitted (MS under submission). The function of L-citrulline to afford heat-stress tolerance has been reported as well (Chowdhury et al., 2017. Journal of Thermal Biology, 69:163-170). Currently, the changes of amino acids in the brain, blood and muscles due to oral L-citrulline is under preparation of a manuscript.
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