Research of viral community for unexplained livestock diarrhea and discovery of novel gastrointestinal viruses

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07718
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Ishikawa Prefectural University (2016-2017); Tokyo University of Agriculture and Technology (2015)
• Principal Investigator: NAGAI Makoto 石川県立大学, 生物資源環境学部, 教授 (10540669)
• Co-Investigator(Kenkyū-buntansha): 青木 博史 日本獣医生命科学大学, 獣医学部, 准教授 (10440067)
• Co-Investigator(Renkei-kenkyūsha): MIZITANI Tetsuya 東京農工大学, 農学部, 教授 (70281681) ; SHIRAI Junsuke 東京農工大学, 連合農学院研究科, 教授 (00355182)
• Research Collaborator: Ito Mika ; Masuda Tsuneyuki ; Akagami Masataka ; Niira Kazutaka
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 家畜 / 下痢症 / ウイルス / メタゲノム解析

Outline of Final Research Achievements

To clarify viral community for unexplained livestock (cattle and pig) diarrhea and discover novel gastrointestinal viruses, bovine and porcine fecal samples were analyzed using a metagenomics approach. We identified a novel picornavirus and new genotypes of Posavirus. Further studies for pathogenicity of these viruses are needed. Multiple possible recombination events in toroviruses, astroviruses, kobuviruses, enterovirueses, and sapoviruses were identified, suggesting that recombination might have contributed to the serological diversity and played an important role in the continued infection and the evolution of viruses in the farms.

Free Research Field

獣医学、感染症学、ウイルス学