2017 Fiscal Year Final Research Report
Inhibition of hypooxia inducible factor as the canine lymphoma treatment
Project/Area Number |
15K07744
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Veterinary medical science
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Research Institution | Yamaguchi University |
Principal Investigator |
Okuda Masaru 山口大学, 共同獣医学部, 教授 (10325243)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
|
Keywords | リンパ腫 / 抗がん剤 / 犬 / 低酸素誘導因子 |
Outline of Final Research Achievements |
Hypoxic conditions in various cancers are believed to relate with their malignancy, and hypoxia inducible factor-1α (HIF-1α) has been shown to be a major regulator of the response to low oxygen. In this study, we examined HIF-1α expression in canine lymphoma using cell lines and clinical samples and found that these cells expressed HIF-1α. Moreover, the HIF-1α inhibitors, echinomycin, YC-1 and 2-methoxyestradiol, suppressed the proliferation of canine lymphoma cell lines. In a xenograft model using NOD/scid mice, echinomycin treatment resulted in a dose-dependent regression of the tumor. Our results suggest that HIF-1α contributes to the proliferation and/or survival of canine lymphoma cells. Therefore, HIF-1α inhibitors may be potential agents to treat canine lymphoma.
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Free Research Field |
獣医内科学
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