Inhibition of hypooxia inducible factor as the canine lymphoma treatment

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07744
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Veterinary medical science
• Research Institution: Yamaguchi University
• Principal Investigator: Okuda Masaru 山口大学, 共同獣医学部, 教授 (10325243)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: リンパ腫 / 抗がん剤 / 犬 / 低酸素誘導因子

Outline of Final Research Achievements

Hypoxic conditions in various cancers are believed to relate with their malignancy, and hypoxia inducible factor-1α (HIF-1α) has been shown to be a major regulator of the response to low oxygen. In this study, we examined HIF-1α expression in canine lymphoma using cell lines and clinical samples and found that these cells expressed HIF-1α. Moreover, the HIF-1α inhibitors, echinomycin, YC-1 and 2-methoxyestradiol, suppressed the proliferation of canine lymphoma cell lines. In a xenograft model using NOD/scid mice, echinomycin treatment resulted in a dose-dependent regression of the tumor. Our results suggest that HIF-1α contributes to the proliferation and/or survival of canine lymphoma cells. Therefore, HIF-1α inhibitors may be potential agents to treat canine lymphoma.

Free Research Field

獣医内科学