2017 Fiscal Year Final Research Report
Elucidation of muscarinic receptor subtypes in regulatory mechanism on ATP, NO and SP releasing nerves in the large intestine
| Project/Area Number |
15K07765
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Gifu University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
齋藤 正一郎 岐阜大学, 応用生物科学部, 准教授 (60325371)
海野 年弘 岐阜大学, 応用生物科学部, 教授 (90252121)
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| Research Collaborator |
TANAHASHI Yasuyuki
SUZUKI Kasumi
ITO Atsushi
SAKUMA Emi
NAGANO Hiroshi
FIROJ Alom
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 神経 / ムスカリン受容体 / 内臓平滑筋 |
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| Outline of Final Research Achievements |
Among M1 to M5 muscarinic receptor subtypes, M2 and M3 receptors are located to not only a smooth muscle cell but also various enteric nerve cells. In this study, to make clear the mechanisms of peristalsis of the large intestine, we have investigated the role of M2 and M3 receptors on the enteric nerves, using muscarinic receptor subtypes knockout mice. In consequence of the study, both M2 and M3 receptor subtypes enhanced the ATP-mediated neuromuscular transmissions in the smooth muscle cells in the large intestine. In addition, M2 receptor-mediated contraction was larger than M3-mediated one. Furthermore, it is also expected that novel signaling molecules may be involved in the both M2 and M3 receptor-mediated contractions in the large intestine.
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| Free Research Field |
獣医薬理学
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