2017 Fiscal Year Final Research Report
Regulation of canine osteoclastogenesis by TGF-beta: a distinct mechanism from murine osteoclastogenesis
| Project/Area Number |
15K07773
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Integrative animal science
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| Research Institution | Azabu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
FUNABA Masayuki 京都大学, 大学院農学研究科, 准教授 (40238655)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | 発生・分化 / 破骨細胞分化 / TGF-β / イヌ |
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| Outline of Final Research Achievements |
We developed a reproducible method to induce osteoclasts from canine bone marrow cells. Mechanism underlying canine osteoclastogenesis partly overlapped to that underlying murine osteoclastogenesis, but role of TGF-β was distinct between canine cells and murine cells- TGF-β negatively regulated differentiation of canine bone marrow cells to osteoclasts, resulting from inhibition of induction of Mitf-E, a tissue-restricted transcription factor to induce osteoclastogenesis. The present research indicates the necessity of the study using cells originated from the species of interest to evaluate factors affecting osteoclast differentiation precisely, because of species-dependent responses.
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| Free Research Field |
分子生物学
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