2017 Fiscal Year Final Research Report
Investigation of the mechanism of the Ca2+ dependent exocrine pancreatic secretion by optogenetic control
Project/Area Number |
15K07782
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Integrative animal science
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Research Institution | Juntendo University |
Principal Investigator |
Nakamura Kyoko 順天堂大学, 医学部, 非常勤助教 (90578858)
|
Co-Investigator(Kenkyū-buntansha) |
濱田 耕造 国立研究開発法人理化学研究所, 脳科学総合研究センター, 研究員 (00311358)
|
Project Period (FY) |
2015-04-01 – 2018-03-31
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Keywords | カルシウムシグナリング / ムスカリン作動性アセチルコリン受容体 / 光刺激 |
Outline of Final Research Achievements |
Intracellular Ca2+ plays important roles as triggers for multiple biological phenomena. The aim of the present study was to clarify the role of intracellular Ca2+ for the release of digestive enzymes from pancreatic acinar cells. We found mAChR subtypes-dependent characteristic patterns of Ca2+ dynamics in the cell induced by an agonist (ACh). However, the relationship between the Ca2+ dynamics and the enzyme-release remain unknown. In the present study, we tried to get some clues to rule out the relationship between the enzyme release and the intracellular Ca2+ dynamics by an optogenetic method.
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Free Research Field |
細胞生理学
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