Identification of the selenoprotein complex functioning epigenetic regulation

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07836
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied molecular and cellular biology
• Research Institution: The University of Tokyo
• Principal Investigator: Hirosawa Mitsuko 東京大学, 大学院農学生命科学研究科(農学部), 助教 (60533982)
• Project Period (FY): 2015-10-21 – 2018-03-31
• Keywords: セレノプロテイン / ヒストン修飾 / DNAメチル化 / ES細胞

Outline of Final Research Achievements

Based on our finding that the selenium which is the essential trace element influences epigenetic regulations, we focused on selenoprotein H (SelH), which is known as the only nuclear protein among selenoproteins. By the analysis of SelH knock down ES cells, we found out that SelH is effect on the DNA methylation status and histone modifications at several pluripotent marker genes, indicating that SelH functions as one of epigenetic factors. We expected that the identification of SelH containing protein complex, which is in progress, might contribute to understanding how SelH participates in epigenetic regulation.

Free Research Field

エピジェネティクス