Preparation of functional glyco-polymers and analysis of their cellular immune activities to develop anti-pollinosis drugs

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07841
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied molecular and cellular biology
• Research Institution: Okayama University
• Principal Investigator: MAEDA Megumi 岡山大学, 環境生命科学研究科, 准教授 (20434988)
• Co-Investigator(Renkei-kenkyūsha): KIMURA Yoshinobu 岡山大学, 大学院環境生命科学研究科, 教授 (70195387) ; OKANO Mitsuhiro 国際医療福祉大学, 医学部, 教授 (60304359)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 糖鎖ポリマー / 花粉アレルゲン / N-グリカン / 植物抗原性糖鎖 / ルイスa抗原 / Th2免疫応答 / 樹状細胞 / γ-ポリグルタミン酸

Outline of Final Research Achievements

Three types of glycopolymers bearing multivalent N-glycans (plant complex type, high-mannose type, or animal complex type) were synthesized. Their suppressive functions on Th2 cellular immune response induced by Japanese cedar pollen allergen, Cry j1, were analyzed by using dendritic cells. And then, structural features of newly identified Japanese cypress pollen allergen, Cha o3, were analyzed. The glycoform of Cha o 3 is similar to those of major glycoallergens in cedar or cypress pollens (Cry j1 and Jun a1).

Free Research Field

糖鎖生物学，生化学，免疫学