Synthetic study of ellagitannins based on coupling reactions between two aromatic rings

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07854
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: University of Toyama
• Principal Investigator: Abe Hitoshi 富山大学, 大学院理工学研究部(工学), 教授 (70221728)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 全合成 / 芳香族化合物 / カップリング反応 / グルコース / ポリフェノール

Outline of Final Research Achievements

Although ellagitannins, which are natural polyphenol compounds, composed of only limited structures, glucose and gallic acid, many kinds of compounds have been known. Since ellagitannin compounds often exhibit interesting biological activities, they have been expected to be medicinal seeds. However, studies on organic synthesis of ellagitannins have insufficiently progressed, and a few examples of total synthesis of simple ellagitannins have been reported. In this study, we challenged syntheses of complex-structured ellagitannins based on coupling reactions between two gallic acids, involving the C-C or C-O oxidative coupling.

Free Research Field

有機合成化学