2017 Fiscal Year Final Research Report
New development of cycloaddition reactions using cyclobutanones
| Project/Area Number |
15K07855
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIMURA Tomoyuki 金沢大学, 医薬保健研究域薬学系, 准教授 (20432320)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | シクロブタノン / 付加環化 |
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| Outline of Final Research Achievements |
1,4-Zwitterionic intermediates which were generated by activation of 3-ethoxycyclobutanones with an appropriate Lewis acid reacted with azobenzenes, quinolines, isoquinolines, ynamides, nitrosobenzenes, and reactive alkynes gave the corresponding 6-membered cyclic compounds by formal [4+2] cycloaddition reactions. A zwitterionic intermediate generated from 3-phenylcyclobutanones reacted aromatics to afford Friedel-Crafts adducts. Also, an adduct between 1,4-ketoaldehyde and tosylhydrazine rected with nucleophiles under activation with a Lewis acid to give dihydropyridazines.
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| Free Research Field |
有機合成化学
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