2017 Fiscal Year Final Research Report
Discovery of new anti-infectives based on chemical biology
| Project/Area Number |
15K07867
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Research Collaborator |
NAGAI KENICHIROU 北里大学, 薬学部, 助教 (30321649)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | ケミカルバイオロジー / 抗感染症剤 / MRSA / 結核症 / MAC症 / 真菌症 |
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| Outline of Final Research Achievements |
1) In the course of screening program of microbial origins, we discovered new macrolactam and anthraquinone compounds that exhibit antimycobacterial activity against M. bovis BCG, M. avium and M. intraceullare. 2) We studied the mechanism of action of microbial small compounds with unique chemical structure and biological activity. We found that stemphone is bound to FemA, leading to the inhibition of the enzymatic activity of FemA. Furthermore, we searched for binding proteins of tanzawaic acid in the lysate of R. oryzae and identified homoisocitrate dehydrogenase as a potential target protein.
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| Free Research Field |
天然物化学
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