Development of fluorescent quinazolines as ion probes

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07868
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Sophia University
• Principal Investigator: Suzuki Yumiko 上智大学, 理工学部, 准教授 (20295546)
• Research Collaborator: MOTOYAMA Miho 上智大学, 大学院・理工学研究科 ; OTAKE Ryo 上智大学, 大学院・理工学研究科 ; FUJIMAKI Yuki 上智大学, 大学院・理工学研究科
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 蛍光団 / 分子プローブ / キナゾリン

Outline of Final Research Achievements

Novel fluorescent quinazolines were designed and synthesized, including derivatives with high quantam yield, red-emission, and large Stokes shift. The HOMO-LUMO energy gaps calculated from the results of UV spectra and CV experiments were consistent with DFT calculation.
Synthesized quinaolines with a metal-recognition moiety responded to a certain type of metal ions. An anti-cancer fluorescent quinazoline was used as a fluorescent probe in cultured cancer cells to visualize its intracellular distribution by fluorescence microscopy. It can be used as a tool for further study to elucidation of its action mechanism.

Free Research Field

有機化学