Development of new palladium catalyzed reactions utilizing the characteristic property of the ligand : switching of reaction pathway

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07871
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Toho University
• Principal Investigator: KATO Keisuke 東邦大学, 薬学部, 教授 (80276609)
• Co-Investigator(Kenkyū-buntansha): 日下部 太一 東邦大学, 薬学部, 講師 (00600032) ; 高橋 圭介 東邦大学, 薬学部, 准教授 (60380854) ; 高山 博之 日本薬科大学, 薬学部, 准教授 (60406634)
• Co-Investigator(Renkei-kenkyūsha): MOCHIDA Tomoyuki 神戸大学, 理学研究科, 教授 (30280580)
• Research Collaborator: HOU Tei ; ARIYAMA Tomohiro ; LI Tou ; CHIN Yu ; YOGESH Daulat Dhage
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: カルボニル化 / リガンド / 環化‐不斉二量化

Outline of Final Research Achievements

Previously, we found that bis(oxazoline) (box) ligand enhances the alkynophilicity of palladium (II), and we were successful in developing CCC-coupling reaction. Herein we report some useful findings based on the characteristic properties of ligand, 1) Box-palladium complexes catalyzed hydration of alkynes 2) Box-palladium complexes catalyzed cyclization- cyclization asymmetric coupling reaction of (ortho-alkynyl phenyl) (methoxymethyl) sulfides 3) Box-palladium complexes catalysed CCC-coupling reaction using molecular oxygen as the terminal oxidant 4) Palladium catalyzed ligand controlled synthesis of heterocycle-carboxylates and diheteroarylketones.

Free Research Field

医歯薬学