Synthesis and Reaction of N-Allenylimides

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07881
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical pharmacy
• Research Institution: Hiroshima International University
• Principal Investigator: Sueda Takuya 広島国際大学, 薬学部, 准教授 (40260682)
• Co-Investigator(Kenkyū-buntansha): 柳田 玲子 広島国際大学, 薬学部, 教授 (80239821)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: N-アレニルイミド / アレニミド / ヘテロ環合成 / N-アルキニルイミド / イニミド / アレナミド / イナミド

Outline of Final Research Achievements

Among the heteroatom-substituted alkynes and allenes, those with nitrogen substitutions have become an important building block in modern organic synthesis. In contrast to the well-defined ynamides and allenamides, to date, there are little examples of imide derivatives. We have recently reported the Cu-catalyzed coupling of alkynyl(triaryl)bismuthonium salts with imides to furnish the first reliable synthetic method of ynimides. Now we found a first convenient approach for the synthesis of internal allenimides via silver-mediated isomerization of ynimides. Allenimides could be used as synthetic building units in the synthesis of heterocyclic compounds.

Free Research Field

有機合成化学