Evaluation of molecular state of drug nanosuspensions by suspended-state NMR spectroscopy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07885
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Chiba University
• Principal Investigator: Higashi Kenjirou 千葉大学, 大学院薬学研究院, 准教授 (40451760)
• Co-Investigator(Kenkyū-buntansha): 森部 久仁一 千葉大学, 大学院薬学研究院, 教授 (50266350)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 薬物ナノ懸濁液 / NMR / 固液界面 / 運動性 / 分子間相互作用 / 結晶多形 / 非晶質 / 湿式粉砕

Outline of Final Research Achievements

Two species of drug nanosuspensions prepared by wet-milling were evaluated by suspended-state NMR spectroscopy. We succeeded in directly clarifying the molecular state of both drug and stabilizer of drug nanoparticle in suspended-state. The knowledge obtained in this study provides a new insight into the mechanism of formation and stabilization of drug nanosuspensions. This study also shows that suspended-state NMR spectroscopy is a useful analytical method for quality assessment of drug nanosuspension formulations. We expect that this study will become a new index in development for drug nanosuspension and will be a help to design a new drug nanosuspension formulations of high quality.

Free Research Field

物理薬剤学