Development of two-layer sheet formulation for application to liver surface to attain specific local chemotherapy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07891
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Nagasaki University
• Principal Investigator: NISHIDA Koyo 長崎大学, 医歯薬学総合研究科(薬学系), 教授 (20237704)
• Research Collaborator: SHIMOKAWA Kenta ; HIRATA Haruna
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: コントロールドリリース / DDS製剤 / 薬物吸収

Outline of Final Research Achievements

We tried to manufacture the two-layer sheet formulation containing anticancer drug 5-FU and metabolic inhibitors for application to liver surface. In addition, we examined the influence of viscous additives on the hepatic disposition of 5-FU, aiming to optimize the sheet formulation. We could manufacture the two-layer sheet formulation containing anticancer drug 5-FU for application to liver surface by employing biodegradable macromolecules and hydroxypropyl cellulose. The two-layer sheet could increase the availability of 5-FU in the specific region in the liver. Moreover, we found that the accumulation of 5-FU in the liver was improved in the tumor mice model.

Free Research Field

薬剤学