Nondestructive bioactivity evaluation of molecular orientated hybrid bone cell scaffold by vibration spectroscopy

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07902
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Musashino University
• Principal Investigator: OTSUKA Makoto 武蔵野大学, 薬学研究所, 教授 (90160548)
• Co-Investigator(Kenkyū-buntansha): 佐々木 哲朗 静岡大学, 電子工学研究所, 特任教授 (20321630)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: 振動分光法 / 分子配向性 / 骨細胞スキャホールド / 非破壊・非接触生体活性評価 / 有機無機複合体 / テラヘルツスペクトル / 近赤外スペクトル / 多変量解析

Outline of Final Research Achievements

As a cell scaffold for bone cells, organic/inorganic complexes such as carbonate apatite nano-particulates and, collagen, gelatin or cellulose derivatives complexes (BS) were created as medical materials with molecular orientation. In order to evaluate the high bioactive function of the medical materials, the organic/inorganic complexes were measured by non-destructive and non-contractive methods such as terahertz (THz), Raman or near infrared (NIR) spectroscopy with chemometrics.　In addition, BS containing osteogenic drugs were created based on this material.　Whether the cellular activity of the BS depends on the bone geometry structure was measured by non-destructive, non-contact THz or NIR and multivariate analysis was performed.

Free Research Field

物理系薬学