2017 Fiscal Year Final Research Report
Development of novel functional ionic liquid nanoparticles applicable for multicolor imaging of fluorine-MRI
| Project/Area Number |
15K07906
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Physical pharmacy
|
|---|
| Research Institution | Kyoto Pharmaceutical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2015-10-21 – 2018-03-31
|
| Keywords | イオン液体 / ナノ粒子 / NMR / MRI / イメージング / 癌 |
|---|
| Outline of Final Research Achievements |
For the development of multicolor imaging of fluorine-MRI, the aim of this study was to prepare the ionic liquid nanoparticles (ILNPs) using the ionic liquid (IL) having fluorine atoms, to evaluate their pharmacodynamics in mice and further to synthesize a novel fluorine-MRI probe. The NMR spectroscopic results, 1H-, 19F, 31P- and 1H-1H NOESY, showed that the ILNP formed an IL-in-water type emulsion in which droplets of IL were surrounded by the surfactants. In addition, the ILNP accumulated higher in kidney than in liver, indicating that fluorine-containing anions of IL were immediately released from the ILNP in blood circulation after the administration in mice. Also, a fluorine-MRI probe could be newly synthesized from the glutathione, which is a substrate for γ-glutamyltransferase which exists in high concentration in cancer cells.
|
| Free Research Field |
分析化学
|
