Development of nucleic acids carriers equipped with tumor microenvironment-sensitive peptides for the therapy of metastatic liver cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07907
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Kyoto Pharmaceutical University
• Principal Investigator: Hama Susumu 京都薬科大学, 薬学部, 講師 (60438041)
• Co-Investigator(Renkei-kenkyūsha): KOGURE Kentaro 徳島大学, 薬学部, 教授 (70262540)
• Research Collaborator: HASAN Mahadi ; KIRIMURA Naoko ; SUZUKI Satoko ; NiSHI Takayuki ; MATSUI Ryo
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: ドラッグデリバリーシステム / 腫瘍微小環境

Outline of Final Research Achievements

To develop novel therapeutic procedure for metastatic liver cancer by using tumor microenvironment, in this study, a novel peptide CTR-SAPSP was designed. CTR-SAPSP has tumor permeability and slightly acidic pH-sensitivity. The tumor permeability of nucleic acids carriers modified with CTR-SAPSP was more potent than that of conventional carriers. Moreover, nucleic acids carriers modified with CTR-SAPSP were delivered into the cytoplasm of cells in response to slightly acidic pH. Besides, carriers encapsulating the core composing of siRNA and pH-sensitive peptide SAPSP showed more potent knockdown effect via the effective cytoplasmic release of siRNA. Collectively, nucleic acids carriers equipped with tumor microenvironment-sensitive peptides are expected as a novel therapeutic procedure for metastatic liver cancer.

Free Research Field

薬物送達学