2017 Fiscal Year Final Research Report
Development of a redox sensitive liposome for diagnosis and treatment for liver damages
| Project/Area Number |
15K07912
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | Sojo University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TAKESHITA Keizo 崇城大学, 薬学部, 教授 (70175438)
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| Project Period (FY) |
2015-04-01 – 2018-03-31
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| Keywords | レドックス / 酸化ストレス / ニトロキシルラジカル / リポソーム |
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| Outline of Final Research Achievements |
We synthesized a nitroxyl radical-binding phospholipid and prepared a redox sensitive liposome. It is difficult to measure the in vivo redox by an in vivo ESR technique using a nitroxyl radical in a disease model having renal impairment, because the half-life of a nitroxyl radical is short. However, we achieved increase of retention in the body of the nitroxyl radical by producing a redox sensitive liposome. This would lead to increase of target diseases of non-invasive redox measurement by ESR and MRI, because difference of probe concentration in a body between healthy and disease model animals would decrease.
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| Free Research Field |
生物物理
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