Development of Surface Modified C60 Nanoparticles for a Carbon-Based Nanomedicine

2017 Fiscal Year Final Research Report

• Project/Area Number: 15K07913
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Physical pharmacy
• Research Institution: Sojo University
• Principal Investigator: IOHARA Daisuke 崇城大学, 薬学部, 講師 (40454954)
• Co-Investigator(Renkei-kenkyūsha): ANRAKU Makoto 崇城大学, 薬学部, 教授 (60398245) ; NAKAMURA Hideaki 崇城大学, 薬学部, 講師 (30435151)
• Project Period (FY): 2015-04-01 – 2018-03-31
• Keywords: フラーレンC60 / シクロデキストリン / ナノ粒子 / 光増感剤 / 抗酸化剤 / 吸着炭素

Outline of Final Research Achievements

Fullerene C60 is the nanomaterial composed of 60 carbon atoms. In this study, we developed the C60 nanoparticles which serve as an grate photosensitizer, antioxidant, and adsorbent with low side effect. Efficient photodynamic therapy against tumor growth was achieved by an intravenous injection of C60 nanoparticles followed by photoirradiation. Daily oral administration of C60 nanoparticles suppressed the progression of renal failure. C60(OH)10, contains 10 hydroxyl group in the C60 molecule, was also prepared in the form of nanoparticles. C60(OH)10 nanoparticles scavenged reactive oxygen species and protect the liver injury by suppression of oxidative stress. C60 based nanoparticles have the potential to serve as a new carbon nanomedicine and could be applied to other diseases.

Free Research Field

製剤学